Can a Two-Faced Kinase be Exploited for Osteosarcoma?

“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries

Can the two mechanisms of tumor cell killing by radiation be exploited for therapeutic gain?

The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron track-ends) are involved. Clinical protocols with fractionated doses of about ...

Transductive Learning via Model Selection; Can Overfitting be Exploited?

A novel transductive learning algorithm is proposed, which is based on the use of model selection. In its simplest form there are k possible labels, m labeled points and one unlabeled point. One model is built for each possible classification of the unlabeled point yM+1 = Li, i = 1, ..., k, using all m+1 points and m + 1 labels. Any standard model selection criterion can then be applied to sele...

"Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced": A Response to Recent Commentaries

*Correspondence to: Solomon R. Benatar, Email: [email protected] Copyright: © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided th...

Rapid diagnostic testing for community-acquired pneumonia: can innovative technology for clinical microbiology be exploited?

Two nonsynchronous events have affected the management of community-acquired pneumonia (CAP): spiraling empiricism for CAP and the "golden era" of clinical microbiology. The development of broad-spectrum antibiotics has led to widespread empiric use without ascertaining the etiology of the infecting microbe. Unfortunately, this approach clashes with the second event, which is the advent of mole...